Immune precision medicine as a new opportunity to control canine trypanosomatid diseases - DogIPM PTDC/CVT-CVT/0228/2020
GHTM–Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisboa, Portugal
Faculdade de Medicina Veterinária (FMV), CIISA – Centro de Investigação Interdisciplinar em Sanidade Animal, Universidade de Lisboa, Lisboa, Portugal,
Health Sciences Centre/Federal University of Rio Grande do Norte
(UFRN, Natal, Brasil)
• 1º seminário Outubro 2022
Gabriela Santos Gomes - PhD
Rosa Direito - (**) (***)
Lis Lobo - (Bolseira EU 2020) ***
Mafalda Meunier - MSc *
Ana Sofia Bolas – PhD (*) (**)
Juliana Weber - MSc *
Joana Marques – PhD (*) (**)
Armanda Rodrigues - Post-doc
Raissa Couto - PhD * (CAPES scholarship, Brazil)
Flávia Martins – MSc *
Sara Shone - MSc *
George Nakhratyan - MSc *
Carolina Lopes - MSc *
Bruna Freitas - MSc *
** FCT scholarship
*** Post-doctoral research scholarship
Isabel Fonseca - DVM, PhD
Graça Alexandre-Pires - DVM, PhD
José Meireles - DVM, PhD
Marcos Santos - PhD
Joana Gomes - DVM
Ana Reisinho - DVM, MSc
Alexandra Basso - DVM
Marta Monteiro - PhD *
Rodolfo Leal - DVM, PhD
Marcelo Silva - PhD
Cláudia Moreno - Post-Doc
Felipe Anderson - PhD *
Johny Oliveira - PhD *
Alzira Regina - PhD *
Aline Maria Queiroz - PhD *
Sílvia Donato - PhD * | IHMT/UFRN
Annamairlla Oliveira - MSc *
Kyvia Varela - MSc *
Rosana Macedo - MSc *
Joice C. Branco - MSc *
Celisa Tavares - MSc *
Tatiana Dias-Guerreiro, Joana Palma-Marques, Patrícia Mourata-Gonçalves, Graça Alexandre-Pires, Ana Valério-Bolas, Áurea Gabriel, Telmo Nunes, Wilson Antunes, Isabel Pereira da Fonseca, Marcelo Sousa-Silva, Gabriela Santos-Gomes (2021). African Trypanosomiasis: Extracellular vesicles shed by Trypanosoma brucei brucei manipulate host mononuclear cells. Biomedicines, 9(8): 1056.
Valério-Bolas, S. Mesquita-Gabriel, M. Meunier, J. Marques, L. Lobo, A. Rodrigues, A. Armada, R. Ferreira, I. Cardoso, G. Alexandre-Pires, I. Pereira da Fonseca, G. Santos-Gomes. Leishmaniose canina: Iniciação da resposta imunitária por células dendríticas derivadas de monócitos caninos. XI Jornadas Científicas HMT-NOVA, 10 de dezembro de 2020. Abstract book page 4.
A. Valério-Bolas, S. Mesquita-Gabriel, M. Meunier, J. Marques, L. Lobo, A. Rodrigues, A. Armada, R. Ferreira, I. Cardoso, G. Alexandre-Pires, I. Pereira da Fonseca, G. Santos-Gomes. Modulation of dendritic cells derived from canine monocytes by parasites of the genus Leishmania. Encontro Ciência 2021. 28 a 30 junho. Centro de Congressos de Lisboa, Junqueira - Portugal
The partnership between Portuguese [Global Health and Tropical Medicine (GHMT), Institute of Hygiene and Tropical Medicine (HMT-NOVA) and Faculty of Veterinary Medicine (FMV/ULisboa)] and Brazilian institutions [Health Sciences Center of the Federal University of Rio Grande do Norte (UFRN)] resulted in the project DogIPM, financed by the Foundation for Science and Technology, I.P. which aims to use dendritic cells (DCs) to modulate T lymphocyte activity in canine trypanosomoses.
Annually there are an estimated 700 000 - 1 million new cases of infection with Leishmania in humans, and 20 000 new cases per year of infection with Trypanosoma cruzi.
L. infantum is the etiologic agent of zoonotic visceral leishmaniasis and canine leishmaniasis that occur throughout the Mediterranean basin, the Middle East, and in some parts of Asia and Latin America. Canine leishmaniasis appears to be spreading to other latitudes due to several factors associated with climate change and globalization.
Trypanosoma cruzi parasite causes Chagas disease in humans, wild and domestic animals, constituting an important public health problem in Central and South America. Due to globalization, this neglected tropical disease has been spreading to other geographic areas, such as North America, Japan, Oceania, and Europe, becoming an emerging disease of global concern. So far, there is no vaccine available to prevent ChD or targeted animal therapy.
The project DogIPM represents a first step in precision immune medicine applied to canine diseases caused by trypanosomatids. These tools will make it possible to control the infection, reduce the amount, frequency of administration and toxicity of non-specific therapy currently used, improve treatment adherence, and achieve clinical and parasitic cure.
The researchers of the DogIPM project thus hope to make a valid contribution to controlling Leishmania and Trypanosoma infection, with the development of vaccines to prevent the infection or inducing the most adequate immune response to cure. Controlling neglected parasitic diseases will contribute to improving the health care available to animals and people and will have a positive impact on the evolution of society.
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